Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum

Abstract

Pykhtieieva E. D., Pykhtieieva E. G., Gozhenko A. I. Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum. Journal of Education, Health and Sport. 2018;8(1):391-396. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2652080 http://ojs.ukw.edu.pl/index.php/johs/article/view/6867 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 23.01.2018. Revised: 26.01.2018. Accepted: 31.01.2018. EXPERIMENTAL STUDY OF METALLOTHIONEIN SYNTHESIS IN MODELING HYPERTHERMIC INTRAOPERATIVE INTRAPERITONEAL CHEMOPERFUSION WITH CYSPLATINUM E. D. Pykhtieieva, E. G. Pykhtieieva, A. I. Gozhenko Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine Abstract In an experiment on white wild-type laboratory rats, it was shown that 90 minutes after intraperitoneal administration of cisplatin at a dose of 4 mg / kg as a solution heated to 43 °C, the integral level of metallothionein significantly increased in the organs. Metallothionein actively binds toxic compounds of metals, including platinum. This may be one of the main reasons for developing resistance to platinum drugs with repeated courses of chemotherapy. Fast inductive synthesis of MT with the introduction of heavy metal compounds is one of the mechanisms of adaptation of the organism to the introduction of a highly toxic platinum compound. The binding of platinum to the sulfhydryl groups of metallothionein reduces the side effect of cisplatin while simultaneously decreasing its antitumor activity. It is not recommended to use the main metallothionein inducers (Zn, Se, antioxidants) in patients with cisplatin sensitive tumors before chemotherapy courses. Key words: cisplatin, kidneys, liver, metallothionei