Tropical deforestation, inevitably, leads to the local loss of bryophyte species. Recent studies show that the degree of species loss may vary considerably and depends on the scale or amount of habitat change that has occurred. Predictably, the shade epiphytes are most seriously affected by disturbance. An estimated 10% of the bryophyte species of neotropical rain forests are under threat. Based on data from recent monographs, a first list of 19 endangered and 27 rare species of these forests is presented. Critical areas for threatened species include Costa Rica and Panama, the Greater Antilles, the Chocó, southeastern Brazil, and parts of Amazonia. Protection of as much as possible of the remaining natural rain forest area seems the best approach to the conservation of the tropical bryophyte flora