Color poster with text, models, and images.Prolyl-tRNA synthetases belong to a class of enzymes that play a pivotal role in
the protein synthesis. These enzymes are responsible for attaching the amino
acid, proline, to the 3β end of the prolyl-tRNA. The structures and domain
architectures of these enzymes differ considerably between human and their
pathogenic analogs. Identifying the differences of recognition elements present
in the two active sites can lead to selective inhibitors based on structure. In the present study, computer-aided docking and simulations have been carried out on several substrate (proline) and inhibitor (halofuginone) analogs.National Institute of Health; University of Wisconsin--Eau Claire Office of Research and Sponsored Program