Comparing SMB Chromatography with Low Capacity/High Selectivity and High Capacity/Low Selectivity Chiral Stationary Phases

Abstract

Simulated moving bed (SMB) chromatography is increasingly applied in the pharmaceutical industry. Numerous chiral stationary phases (CSPs) exist for enantioseparations. The adsorption behavior of the enantiomers can differ significantly on these CSPs (depending on system, mobile phase composition, adsorption mechanisms, ...). Frequently several CSPs are available to perform the same separation. Objective of this work is to examine the impact of the adsorption equilibrium functions on the productivity in enantioseparations by SMB chromatography for different combinations of CSP/mobile phase