Histopathologic and Morphometrie Parameters in the Assessment of Oral Lichen Ruber

Abstract

Kod 30 ispitanika s OLR uzeti su biopsijski uzorci s oralne sluznice u svrhu određivanja histopatoloških obilježja. Uzorci su obrađeni klasičnom histološkom preparatornom tehnikom. Studija je pokazala karakteristične promjene za OLR: hiperparakeratozu kod 53,3% ispitanika uz pojačan nalaz keratohijalinih granula kod 23,3%, akantozu epitela kod 50% uz nalaz papilomatoze kod 66,6%, vakuolarnu degeneraciju citoplazme bazalnih stanica kod 50%, te infiltraciju limfocitima u lamini propriji kod 60% i povećan nalaz makrofaga subbazalno u 40% uzoraka. Na temelju prisutnih histopatoloških obilježja predloženi su detaljniji histopatološki kriteriji za oralni lichen ruber koji mogu biti od dijagnostičke vrijednosti u histološkoj evaluaciji oralnih lezija klinički sličnih oralnom lichen ruberu.Biopsies were taken from thirty examinees with oral lichen ruber in order to establish histopathologic criteria. Specimens were prepared by means o f routine histopathologic procedures. In this study results have shown characteristic changes for OLR: hyperparakeratosis in 53,3% specimens with increased finding o f keratohyaline granules in stratum granulosum in 23,3%, acanthosis in 50% with papillomatosis in 66,6%, vacuolar degeneration o f basal cells cytoplasm in 50%, and subepithelial lymphocytes infiltrate in 60% with increased macrophage finding in 40% o f specimens. On the basis o f present histopathologic characteristics histopathologic criteria for O LR are suggested which can be o f diagnostic value in the histological evaluation o f oral lesions that are clinical similar to OLR