School of Dental Medicine, University of Zagreb, Croatian Dental Society - Croatian Medical Association
Abstract
Uvod: Propolis, smolasta tvar koju proizvode pčele, uporablja se u narodnoj medicini više od dvije tisuće godina. No, njegovi mnogobrojni sastojci mogu djelovati kao potencijalni antigen. Topikalna primjena može uzrokovati nuspojave u usnoj šupljini. Materijali i metode: Retrospektivnom studijom bili su obuhvaćeni pacijenti s oralnim lezijama zbog topikalne uporabe propolisa. Pritom su korišteni podaci iz medicinske dokumentacije pacijenata: izgled i lokalizacija lezija, kada su se pojavili simptomi, terapija i vrijeme cijeljenja te osnovni demografski podaci (dob, spol). Rezultati: Sudjelovalo je dvadeset dvoje pacijenata s lezijama uzrokovanima korištenjem propolisa. Najčešća klinička slika bila je erozivni stomatitis. Simptomi su se obično pojavljivali dva i pol dana nakon uporabe propolisa, iako su se neke lezije pojavile odmah. Većina pacijenata (21/22) uspješno je liječena topikalnim kortikosteroidima. Šestero je bilo podvrgnuto alergološkom testiranju – troje je bile pozitivno, a troje negativno. Zaključak: Topikalni preparati propolisa mogu prouzročiti teške oralne nuspojave. Dosadašnje spoznaje ne podupiru njegovu široku primjenu u terapiji bolesti usta.Objectives: Propolis, a resinous substance produced by bees, has been used in popular medicine for more than 2000 years. Material and methods: Numerous compounds of propolis can act as potent sensitizers. Topical application of propolis can induce oral lesions. Patients with oral lesions due to topical propolis are presented. Basic demographic (age, gender) and clinical data (appearance and localization of the lesions, symptoms onset, treatment and healing time) were recorded. Results: Twenty two patients with propolis-induced lesions were evaluated. The most common occurring presentation was erosive stomatitis. Symptoms tended to appear 2.5 days after propolis use although some lesions occurred immediately after utilization. Majority of patients (21/22) were successfully treated with topical corticosteroids. Six patients underwent patch testing, 3 patients were positive and 3 were negative. Conclusion: Topical propolis can have serious oral side effects. Current knowledge does not support its widespread use in the treatment of oral diseases
