A Dubra

A Roorda

AG Bennett

BS Edwards

C Cuspidi

CY Cheung

D Baleanu

D Rizzoni

E Koch

EL Schiffrin

G Mancia

G Michelson

HG Scheie

J Tam

JA Martin

JM Harazny

K Takayama

LD Hubbard

M Ritt

MD Knudtson

MV Lehmann

N Chapman

NM Keith

OH M

P Bedggood

RE Schmieder

S Arichika

TT Chui

TY Chui

TY Wong

Y Muraoka

Scientific Reports

AbstractThe wall-to-lumen ratio (WLR) of the vasculature is a promising early marker of retinal microvascular changes. Recently, adaptive optics scanning laser ophthalmoscopy (AOSLO) enabled direct and noninvasive visualization of the arterial wall. Using AOSLO, we analyzed the correlation between age and WLR in 51 normal subjects. In addition, correlations between blood pressure and WLR were analyzed in 73 subjects (51 normal subjects and 22 hypertensive patients). WLR showed a strong correlation with age (r = 0.68, P &lt; 0.0001), while outer diameter and inner diameter did not show significant correlation with age in the normal group (r = 0.13, P = 0.36 and r = −0.12, P = 0.41, respectively). In the normal and hypertensive groups, WLR showed a strong correlation with systolic and diastolic blood pressure (r = 0.60, P &lt; 0.0001 and r = 0.65, P &lt; 0.0001, respectively). In conclusion, AOSLO provided noninvasive and reproducible arterial measurements. WLR is an early marker of morphological changes in the retinal arteries due to age and blood pressure.</jats:p

Shigeta Arichika

Akihito Uji

Sotaro Ooto

Yuki Muraoka

Nagahisa Yoshimura

Crossref

Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy

Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy

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