Bo Hu

Chen Zhao

Chengcheng Jin

Eran Elinav

Fred C. Lam

Glaccum

Hua-Bing Li

Jiyu Tong

Jorge Henao-Mejia

Katherine A. Fitzgerald

Merritt

Naniye Malli Cetinbas

Omer Yilmaz

Richard A. Flavell

Shu Zhu

Stephanie C. Eisenbarth

Till Strowig

Tustison

Xinshou Ouyang

AIMing to block tissue damage
          
            Ionizing radiation kills actively dividing cells such as those in the gut and in the bone marrow. Hu
            et al.
            found a pathological role for the protein AIM2 in irradiation-induced tissue damage. AIM2 is best known for its role in sensing double-stranded DNA in the cytoplasm and alerting the body to infections. It seems that AIM2 also senses DNA damage caused by radiation and then triggers intestinal epithelial cells and bone marrow cells to die. Deficiency in AIM2 protected mice from irradiation-induced gastrointestinal syndrome and hematopoietic failure.
          
          
            Science
            , this issue p.
            765
          </jats:p

Crossref

Science

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

Abstract

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