Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain

Amann, M

Andelova, M

Barkhof, F

Burggraaff, J

Cawley, N

Ciccarelli, O

Collorone, S

Cortese, R

Gasperini, C

Hagens, MH

Killestein, J

Kilsdonk, ID

Lieb, JM

Lissenberg-Witte, BI

Lukas, C

MAGNIMS Study Group

Oreja-Guevara, C

Palace, J

Pantano, P

Rovira, A

Ruggieri, S

Sbardella, E

Wattjes, MP

Wuerfel, J

Multiple Sclerosis Journal

English

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This research has been supported by a programme grant (14-358e) from the Dutch MS Research Foundation (Voorschoten, The Netherlands). The study in London was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3-6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T (p = 0.005). For patients, this was 4.18 and 4.40, respectively (p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training

Hagens, M. H. J.

Burggraaff, Jessica

Kilsdonk, I. D.

Ruggieri, Serena

Collorone, S.

Cortese, R.

Cawley, Niamh

Sbardella, E.

Andelova, M.

Amann, Michael

Lieb, J. M.

Pantano, P.

Lissenberg-Witte, B. I.

Killestein, Joep

Oreja-Guevara, Celia

Wuerfel, Jens

Ciccarelli, Olga

Gasperini, C.

Lukas, Cédric

Rovira, A.

Barkhof, Frederik

Wattjes, Mike P

Universitat Autònoma de Barcelona

Diposit Digital de Documents de la UAB

Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome : A MAGNIMS multicentre study

Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3-6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T ( p = 0.005). For patients, this was 4.18 and 4.40, respectively ( p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training

Hagens, Marloes Hj

Kilsdonk, Iris D

Collorone, Sara

Cortese, Rosa

Sbardella, Emilia

Andelova, Michaela

Lieb, Johanna M

Pantano, Patrizia

Lissenberg-Witte, Birgit I

Gasperini, Claudio

Lukas, Carsten

Rovira, Alex

RIMASaud Institutional Repository of the Regional Health System

Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study.

Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio
leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain.
Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between
raters on lesion detection and diagnosis.
Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre
cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received
follow-up brain MRI at 3–6months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time
(McDonald 2010).
Results: In controls, the mean number of lesions per rater was 0.16 at 1.5T and 0.38 at 3T (p=0.005).
For patients, this was 4.18 and 4.40, respectively (p=0.657). Inter-rater agreement on involvement per
anatomical region and dissemination in space and time was moderate to good for both field strengths.
3T slightly improved agreement between experienced raters, but slightly decreased agreement between
less-experienced raters.
Conclusion: Overall, the interobserver agreement was moderate to good. 3T appears to improve the reading for experienced readers, underlining the benefit of additional training

Oxford University Research Archive (ORA)

Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study

Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3–6months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5T and 0.38 at 3T (p=0.005). For patients, this was 4.18 and 4.40, respectively (p=0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3T appears to improve the reading for experienced readers, underlining the benefit of additional training

Oxford University Research Archive

BACKGROUND: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. OBJECTIVES: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. METHODS: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3-6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). RESULTS: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T ( p = 0.005). For patients, this was 4.18 and 4.40, respectively ( p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. CONCLUSION: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training

MAGNIMS Study Group, .

UCL Discovery

Supplementary table 1. MRI sequence parameters per centre for 1.5T and 3T Abbreviations: Ax = axial, DIR = double inversion recovery, FLAIR = fluid-attenuated inversion recovery, GE = General Electric, GRE = gradient echo, NA= not applicable, PD = proton density, Sag = sagittal, SE = spin-echo, T = Tesla, TE = echo time, TR = repetition time, TSE = turbo spin-echo  Center 1.5T 3T  Vendor Parameters Head Spinal cord Vendor Parameters Head Spinal cord   Sequence 3D T1 3D FLAIR 2D PD/T2 3D DIR 2D T1 +c 2D T1 2D PD/T2  Sequence 3D T1 3D FLAIR 2D PD/T2 3D DIR 2D T1 +c 2D T1 2D PD/T2   Type GRE TSE TSE TSE SE SE TSE  Scantype GRE TSE TSE TSE SE SE TSE   Slice orientation Sag Sag Ax Sag Ax Sag Sag  Slice orientation Sag Sag Ax Sag Ax Sag Sag VU University Medical Center Amsterdam GE Signa HDxt Measured voxel size (mm) 1.0x1.0x1.0 1.4x1.4X1.2 0.65x1.0x3.0 1.4x1.4x1.2 0.65x1.0x3.0 0.9x1.5x3.0 0.9x1.5x3.0 GE Discovery MR750 Measured voxel size (mm) 1.0x1.0x1.0 1.1x1.1x1.2 0.65x1.0x3.0 1.1x1.1x1.2 0.78x1.0x3.0 0.93x1.5x3.0 0.93x1.5x3.0 TR (ms) 12.4 6500 4000 6500 480 450 2400 TR (ms) 8.2 8000 9415 8000 660 589 3598/3400 TE (ms) 5.2 115 20/102 111 9 14 15/98 TE (ms) 3.2 130 20/112 125 9 8.7 9.6/80 Flip angle (degrees) 12       Flip angle (degrees) 12       Turbo factor  191 10 191   10 Turbo factor  230 24 230   21 Inversion times (ms) 450 1994  1694/2692    Inversion time (ms) 450 2340  1450/3148    University Hospital Basel Siemens Avanto Measured voxel size (mm) 1.0x1.0x1.0 1.0x1.0x1.0 1.0x1.0x3.0 1.33x1.33x1.5 1.0x1.0x3.0 0.67x0.84x3.0 0.67x0.84x3.0 Siemens Verio Measured voxel size (mm) 1.0x1.0x1.0 1.0x1.0x1.0 1.0x1.0x3.0 1.33x1.33x1.5 1.0x1.0x3.0 0.67x0.84x3.0 0.67x0.84x3.0 TR (ms) 2700 6000 3980 7500 552 400 2500/4440 TR (ms) 1570 5000 3570 7400 650 500 2500/3450 TE (ms) 3.37 352 9.3/112 307 17 12 9.5/102 TE (ms) 2.67 402 9.3/93 324 8.4 10 8.1/102 Flip angle (degrees)  8       Flip angle (degrees)  9       Turbo factor  141 7 256   6/25 Turbo factor  141 7 256   6/21 Inversion times (ms) 950 2200  450/3000    Inversion times (ms) 900 1800  450/3000    St. Josef Hospital Bochum Siemens Avanto Measured voxel size (mm) 1.1x1.1x1.0 1.0x1.0x1.0 0.45x0.45x3.0 1.0x1.0x1.5 0.5x0.5x3.0 0.8x0.8x3.0 1.0x1.0x3.0 Philips Achieva Measured voxel size (mm) 1.1x1.1x1.0 1.0x1.3x1.0 1.0x1.0x3.0 1.0x1.0x1.1.2 1.0x1.0x3.0 0.48x0.48x3.0 0.48x0.48x3.0 TR (ms) 10 4800 4720 7500 450 550 2800 TR (ms) 10 5000 3000 5500 635 462 3696 TE (ms) 4.6 291 9.9//89 308 8.7 11 22 TE (ms) 4.2 354 118 328 17 8 120 Flip angle (degrees) 8       Flip angle (degrees)  15       Turbo factor  204 10 226   12 Turbo factor  182 8 173   34 Inversion times (ms) 1000 1650  450/3000    Inversion times (ms) 1100 1900  440/2550    UCL Institute of Neurology London Siemens Avanto Measured voxel size (mm) 1.0x1.0x1.0 1.0x1.0x1.0 0.57x0.57x3.0 NA 0.78x0.78x3.0 0.94x0.94x3.3 0.94x0.94x3.3 Philips Achieva Measured voxel size (mm) 1.0x1.0x1.0 1.2x1.2x1.2 1.0x1.3x3.0 1.2x1.2x1.2 1.0x1.3x3.0 1.0x1.8x3.0 1.0x1.8x3.0 TR (ms) 1900 6500 7090 NA 984 476 3030 TR (ms) 6.9 8000 3500 5800 625 600 3500/3900 TE (ms) 3.37 202 12/81 NA 8.4 8.6 11/101 TE (ms) 3.1 388 8/19 250 10 8 22/78 Flip angle (degrees)  15       Flip angle (degrees)  8       Turbo factor  125 6 NA   8 Turbo factor  120 10 154   6/24 Inversion times (ms) 1100 2000  NA    Inversion times (ms) 821 2400  2600/425    Hospital Clínico San Carlos Madrid GE Signa HDxt Measured voxel size (mm) 0.98x0.98x1.0 0.98x0.98x1.0 0.48x0.48 x4.0 NA 0.48x0.48 x4.0 0.4 x0.47 x3.3 0.59x0.59x3.3  Measured voxel size (mm) 0.98x0.98x1.0 0.98x0.98x1.0 0.49x0.49x4.0 NA  0.48x0.48 x4.0 1.3 x 1.3 x 3.0 0.63x0.63x3.3 TR (ms) 10 6000 2500 NA 540 540 2060 TR (ms) 10 6000 2500 NA 540 460 2040 TE (ms) 4.2 136 10/120 NA 7.3 8.6 13/118 TE (ms) 4.2 135 10/108 NA 7.5 8.4 13/118 Flip angle (degrees)  12       Flip angle (degrees)  12       Turbo factor  220 12 NA   12 Turbo factor  220 12 NA   18 Inversion times (ms) 450 1837  NA    Inversion times (ms) 450 1840  NA    Sapienza University of Rome Siemens Avanto Measured voxel size (mm) 1.0x1.0x1.0 1.2x1.2x1.3 0.6x0.6x3.0 NA 1.0x0.8x3.0 0.9x0.8x3.0 1.0x0.8x3.0 Siemens Verio Measured voxel size (mm) 1.0x1.0x1.0 1.0x1.0x1.0 0.6x0.6x3.0 NA 1.0x0.8x3.0 1.0x0.8x3.0 1.0x0.8x3.0 TR (ms) 1900 6500 6650 NA 923 458 2500/3670 TR (ms) 1900 5000 5970 NA 628 600 2500/3000 TE (ms) 3.37 202 12/81 NA 8.4 9.4 9.8/118 TE (ms) 2.93 395 10/103 NA 9.8 9.4 7.8/107 Flip angle (degrees)  15       Flip angle (degrees)  9       Turbo factor  125 6 NA   6/24 Turbo factor  141 6 NA   6/27 Inversion times (ms) 1100 2000  NA    Inversion times (ms) 900 1800  NA     

NARCIS 

Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3–6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T ( p = 0.005). For patients, this was 4.18 and 4.40, respectively ( p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training. </jats:sec

Marloes HJ Hagens

Jessica Burggraaff

Iris D Kilsdonk

Serena Ruggieri

Sara Collorone

Rosa Cortese

Niamh Cawley

Emilia Sbardella

Michaela Andelova

Michael Amann

Johanna M Lieb

Patrizia Pantano

Birgit I Lissenberg-Witte

Joep Killestein

Celia Oreja-Guevara

Jens Wuerfel

Olga Ciccarelli

Claudio Gasperini

Carsten Lukas

Alex Rovira

Frederik Barkhof

Mike P Wattjes

null null

Crossref

Archivio della ricerca- Università di Roma La Sapienza

https://ora.ox.ac.uk/objects/uuid:52087e7d-8d38-456a-88eb-c6b063bed0c9/files/m3ba6937053275ca668b62b51f2de42d0

Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study

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