Sindrom sustavnoga upalnoga odgovora i sindrom višestrukog zatajivanja organa u pasa s babeziozom

Abstract

Canine babesiosis caused by Babesia canis canis is one of the commonest canine diseases in Croatia, especially in the area of capital city, Zagreb. Babesiosis is a multi-system disease and multiple organ dysfunction syndrome (MODS) develops from systemic inflfl ammatory response syndrome (SIRS), which is a hallmark of babesiosis. Therefore, the purpose of this study was to conduct detailed research of the incidence of SIRS and MODS as well as organ systems involvement in a large number of dogs naturally infected with B. canis canis in Croatia. Out of 332 dogs with canine babesiosis, 226 dogs (68 percent) fulfilled the SIRS criteria and were considered as SIRS positive. Among them 151 dogs (67%) fulfilled two SIRS criteria, 66 dogs (29%) fulfilled three criteria and only 9 dogs (4%) fulfilled all four SIRS criteria. Thirty-three dogs (10%) fulfilled the MODS criteria. Among them 22 dogs (66%) had two organ involvement, 10 dogs (31%) had three organ involvement and in only 1 dog (3%) four organ dysfunction was present. The incidence of organ involvement in MODS was as follows: renal dysfunction (30/33), liver dysfunction (20/33), muscle involvement (19/33), lung dysfunction (16/33), cerebral involvement (3/33). Among MODS positive dogs, 22 dogs died and 11 dogs survived babesiosis. In dogs with two organ involvement, survival was 45%, in dogs with three organ involvement survival was 10%, while in the group with four organ dysfunction mortality was 100%. It can be concluded that in cases of canine babesiosis caused by B. canis canis, in which MODS developed, an unfavourable outcome should be taken into consideration.Babezioza uzrokovana praživotinjom Babesia canis canis jedna je od najčešćih bolesti pasa u Hrvatskoj, osobito u području oko glavnoga grada Zagreba. Babezioza je bolest koja zahvaća više organskih sustava, a sindrom višestrukoga zatajenja organa (engl. multiple organ dysfunction syndrome) razvija se iz sindroma sustavnog upalnog odgovora (engl. systemic infl ammatory response syndrome), koji je karakterističan za babeziozu. Cilj ovoga rada bio je proučiti pojavnost sindroma sustavnog upalnog odgovora i sindroma višestrukoga zatajenja organa na velikom broju pasa koji boluju od babezioze, kao i učestalost zahvaćenosti pojedinih organskih sustava u sindromu višestrukoga zatajenja organa. Od 332 psa s potvrđenom babeziozom 226 pasa (68%) razvilo je sindrom sustavnog upalnog odgovora. Od njih je 151 pas (67%) ispunio 2 kriterija, 66 pasa (29%) ispunilo je 3 kriterija, dok su u 9 pasa (4%) bila ispunjena sva četiri kriterija. Trideset i tri psa ispunila su kriterije za sindrom višestrukoga zatajenja organa. Od njih su 22 psa (66%) imala zahvaćena po dva organska sustava, 10 pasa (31%) imalo je zahvaćena tri organska sustava, dok je samo 1 pas (3%) imao zahvaćena četiri organska sustava. Najčešće zahvaćeni organski sustavi u sindromu višestrukoga zatajenja organa bili su: uropoetski sustav (30/33), jetra (20/33), mišićje (19/33), dišni sustav (16/33) i središnji živčani sustav (3/33). Od pasa koji su razvili sindrom višestrukoga zatajenja organa 22 su uginula dok ih je 11 preživjelo babeziozu. Preživljavanje pasa u kojih su bila zahvaćena 2 organska sustava bilo je 45%, sa zahvaćena 3 organska sustava bilo je 10%, dok je smrtnost sa zahvaćena 4 organska sustava iznosila 100%. Na temelju rezultata se može zaključiti da je razvoj sindroma višestrukoga zatajenja organa u babeziozi pasa prognostički značajan i da u slučaju da se sindrom razvije raste i vjerojatnost nepovoljnog ishoda