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Beilstein Journal of Organic Chemistry

English

Compared to cholesterol, hydroxycholesterols contain an additional hydroxy group in the alkyl chain and are able to efficiently cross the brain–blood barrier. Therefore, they are responsible for the sterol transfer between brain and circulation. The current study compares the membrane properties of several hydroxycholesterols with those of cholesterol using 2H NMR spectroscopy, a membrane permeability assay, and fluorescence microscopy experiments. It is shown that hydroxycholesterols do not exert the unique impact on membrane properties characteristic for cholesterol with regard to the influence on lipid chain order, membrane permeability and formation of lateral domains.</jats:p

Malte Hilsch

Ivan Haralampiev

Peter Müller

Daniel Huster

Holger A Scheidt

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Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism

https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-13-71.pdf

Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism

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