Chuan-Hua Yang

Jing-Chang Sun

Miao-Miao Wang

Wen-Qing Yang

Yue-Hua Jiang

Yun-lun Li

Evidence-Based Complementary and Alternative Medicine

English

Endothelial dysfunction and low-grade inflammation are closely associated with hypertension and other cardiovascular diseases. The combination ofUncaria (U)andSemen Raphani (R)is common in traditional Chinese medicine for the treatment of hypertension and heart diseases. We aimed to investigate the therapeutic effect of the combination ofUncariaandSemen Raphanion spontaneously hypertensive rats (SHRs), and valsartan was used as a positive control. In the present study, all extracts decreased systolic pressure, diastolic pressure, and mean arterial pressure.Ualone showed antihypertensive efficacy and effectively decreased CECs count, whileRalone showed efficacy in relieving inflammatory level. The combination ofUandRshowed enhanced effectiveness at lowering activated CECs and improving endothelial integrity of thoracic aorta and mesenteric artery and normalized the level of plasma biomarkers of endothelial damage. The combination ofUandRdecreased the mRNA level of VCAM-1, Sel-L, TFPI, and Sel-P, while it elevated mRNA expression of FGF-1 and THBD of the thoracic aorta, which may be, at least in part, involved in the mechanism of protective effect on hypertensive endothelial injury.</jats:p

Crossref

Evidence-based Complementary and Alternative Medicine

Enhanced Protective Effect of the Combination of<i>Uncaria</i>and<i>Semen Raphani</i>on Vascular Endothelium in Spontaneously Hypertensive Rats

http://downloads.hindawi.com/journals/ecam/2015/358352.pdf

Enhanced Protective Effect of the Combination of
                    Uncaria

Enhanced Protective Effect of the Combination of Uncaria

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