Patogenezu složene i heterogene bolesti kao što je to rak dojke nije moguće u potpunosti
razjasniti klasičnim metodološkim pristupima koji su se koristi li posljednjih desetljeća
u molekularnoj medicini. Osobito je važno otkriti nove biljege koji bi pomogli u ranoj detekciji
bolesti te služili za razvoj ciljane terapije. Dosadašnji rezultati iz područja istraživanja raka
dojke u kombinaciji s globalnim metodama istraživanja statusa ekspresije gena i proteina
pokazali su kako je u patogenezu raka dojke uključen ljudski hormon rasta (hGH) te mehanizmi
autokrine regulacije preko proteina Pax-5. Također je identi fi ciran čitav niz novih potencijalnih
biomarkera kao što su to HOXA1, CHOP SH3GLB1, kazein kinaze, p53, aneksin XI, CDC25C, eIF-
4E i MAP kinaze 7, 14-3-3e, galekti n-1, aneksin-5, aneksin-1, LDH-B, GST-pi, akti n, vimenti n,
HSP70, CK18, moezin, SH3GLB1, SUB1, SND1 i TRIM28, osteoponti n i osteonekti nBreast cancer is a complex and heterogenic disease. Classical molecular medical
approaches cannot be successfully used to completely understand its pathogenesis. In additi
on, fi nding new biological markers that would help in early detecti on and creati on of guided
and specifi c therapy is crucial for the future breast cancer management. The results of
breast cancer research in combinati on with those obtained by large scale methods that examine
the expression status of genes and proteins, have pointed to an important molecule,
namely the human growth hormone (hGH), as a major player in the pathogenesis of breast
cancer. It acts through the autocrine regulati on system where the acti vati on of Pax-5 gene
has been recently confi rmed as well. A large number of new biomarkers, like HOXA1, CHOP
SH3GLB1, casein kinase, p53, annexin XI, CDC25C, eIF-4E, MAP kinase 7, 14-3-3e, galecti n-1,
annexin-5, annexin-1, LDH-B, GST-pi, acti n, vimenti n, HSP70, CK18, moesin, SH3GLB1, SUB1,
SND1 i TRIM28, osteoponti n and osteonecti n, have been recently identi fi ed as well
