A Harrois

A Nencioni

Anatole Harrois

C Ince

Camille Nicolaï

D Backer De

Eric Vicaut

G Tachon

GV Aykut

J Pottecher

Jacques Duranteau

JM Bland

K Yuruk

MJ Massey

Mélanie Flores

O Genzel-Boroviczeny

R Bezemer

RC Arnold

RM Bateman

S Trzeciak

Sophie Hamada

Sébastien Tanaka

Y Sakr

English

Abstract
                Introduction
                We aimed to determine i) the feasibility of nurses taking bedside measurements of microcirculatory parameters in real time in intensive care patients; and ii) whether such measurements would be comparable to those obtained by the classical delayed semi quantitative analysis made by a physician.
              
                Methods
                This prospective observational study was conducted in a university hospital and was approved by our local Institutional Review Board (IRB 00006477). After ICU admission and study inclusion, a set of measurements of macrocirculatory and microcirculatory parameters was taken by the nurse in charge of the patient every 4 h within the first 12 h after admission and before and after every hemodynamic therapeutic intervention. Seventy-four sublingual microvascular measurements were performed with incident dark field illumination (IDF) microscopy in 20 mechanically ventilated patients hospitalized in the ICU.
              
                Results
                There were no significant differences between the microvascular flow index (MFI) taken in real time by the nurses and the delayed evaluation by the physician. In fact, the nurses’ real-time measurement of MFI demonstrated good agreement with the physician’s delayed measurement. The mean difference between the two MFIs was −0.15, SD = 0.28. The nurses’ real-time MFI assessment showed 97 % sensitivity (95 % CI: 84–99 %) and 95 % specificity (95 % CI: 84–99 %) at detecting a MFI &lt;2.5 obtained by a physician upon delayed semiquantitative measurement. Concerning the density, 81 % of the paramedical qualitative density measurements corresponded with the automatized total vessel density (TVD) measurements. The nurses’ real-time TVD assessment showed 77 % sensitivity (95 % CI: 46–95 %) and 100 % specificity (95 % CI: 89–100 %) at detecting a TVD &lt;8 mm/mm2.
              
                Conclusion
                A real-time qualitative bedside evaluation of MFI by nurses showed good agreement with the conventional delayed analysis by physicians. The bedside evaluations of MFI and TVD were highly sensitive and specific for detecting impaired microvascular flow and low capillary density. These results suggest that this real-time technique could become part of ICU nurse routine surveillance and be implemented in algorithms for hemodynamic resuscitation in future clinical trials and regular practice. These results are an essential step to demonstrate whether these real-time measurements have a clinical impact in the management of ICU patients.
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Crossref

Critical Care

Qualitative real-time analysis by nurses of sublingual microcirculation in intensive care unit: the MICRONURSE study

https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-015-1106-3?site=ccforum.biomedcentral.com

Qualitative real-time analysis by nurses of sublingual microcirculation in intensive care unit: the MICRONURSE study

Abstract

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