AG Freifeld

AH Strayer

AS Levey

B Auclair

C Infante-Rivard

GL Drusano

HM Mattoes

J Langgartner

JR Garzón

KM Shea

LZ Benet

U Theuretzbacher

WA Ritschel

BMC Pharmacology and Toxicology

English

Abstract
          
            Introduction
            Patients with febrile neutropenia (FN) exhibit changes in extracellular fluid that may alter the plasma concentrations of beta-lactams and result in therapeutic failure or toxicity. We evaluated the pharmacokinetics of piperacillin/tazobactam in patients with hematological malignancies and FN after receiving chemotherapy at a primary public cancer center.
          
          
            Methods
            This was an open, nonrandomized, observational, descriptive, and prospective study. Samples from 15 patients with hematological malignancies and FN were evaluated after the administration of chemotherapy. Five blood samples were taken from each patient when the antibiotic level was at steady-state 10, 60, 120, 180, and 350 min after each dose. Antibiotic concentrations were measured using gel diffusion with Bacillus subtilis. All study participants provided written informed consent.
          
          
            Results
            We investigated the pharmacokinetics of piperacillin in 14 patients between the ages of 18 years and 59 years and with a mean absolute neutrophil count of 208 cells per mm3 (standard deviation (SD) ± 603.2). The following pharmacokinetic measurements were obtained: maximum concentration, 94.1–1133 mg/L; minimum concentration, 0.47–37.65 mg/L; volume of distribution, 0.08–0.65 L/kg (mean, 0.34 L/kg); drug clearance (CL), 4.42–27.25 L/h (mean, 9.93 L/h); half-life (t1/2), 0.55–2.65 h (mean, 1.38 h); and area under the curve, 115.12–827.16 mg · h/L.
          
          
            Conclusion
            Patients with FN after receiving chemotherapy exhibited significant variations in the pharmacokinetic parameters of piperacillin compared with healthy individuals; specifically, FN patients demonstrated an increase in t1/2 and decreased CL.
          </jats:sec

José C Álvarez

Sonia I Cuervo

Javier R Garzón

Julio C Gómez

Jorge Augusto Díaz

Edelberto Silva

Ricardo Sánchez

Jorge A Cortés

Crossref

Pharmacokinetics of piperacillin/tazobactam in cancer patients with hematological malignancies and febrile neutropenia after chemotherapy

https://bmcpharmacoltoxicol.biomedcentral.com/track/pdf/10.1186/2050-6511-14-59?site=bmcpharmacoltoxicol.biomedcentral.com

Pharmacokinetics of piperacillin/tazobactam in cancer patients with hematological malignancies and febrile neutropenia after chemotherapy

Abstract

Similar works

Full text

Available Versions

Crossref