Tijekom posljednjih petnaestak godina za istraživanje uloge različiti h proteina i mehanizama
nastanka bolesti primjenjuju se sistemski pristupi i analize kojima se istovremeno
prate globalne promjene razine ekspresije velikog broja gena i/ili proteina. Imajući na umu
složene interakcije na razini stanica i činjenicu kako je većina bolesti multi faktorijalnog podrijetla,
takav sistemski pristup najbolji je način stjecanja uvida u funkciju nekog proteina i/ili
mehanizme nastanka bolesti . Proteini “Trefoil Factor Family” ili proteini TFF (TFF1,TFF2, TFF3)
otkriveni su prije više od 25 godina, te je ubrzo postalo jasno kako je njihova uloga u organizmu
iznimno kompleksna. Tek je sistemski pristup istraživanju analize uloge proteina TFF2
razjasnio njegovu ulogu u organizmu pokazujući vezu s imunološkim sustavom.In the last fi ft een years a systemic approach has been widely implemented in
the investi gati on of diff erent proteins’ functi on as well as to elucidate the mechanisms underlying
disease development. Simultaneous monitoring of global changes through gene expression
studies combined with protein patt ern analyses represents the best way to unveil
the functi on of some proteins and/or pathogenesis mechanisms for various disease especially
when knowing that multi ple interacti on patt erns are present inside the cells and that
causes of diseases are oft en multi factorial. Trefoil factor family proteins (TFFs) have been
discovered more than 25 years ago. It has soon become clear that their role in biological
systems is multi factorial and quite complex. A systemic approach to their analyses brought
out the role of TFF2 involvement in the processes relevant for the immune system
