Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
The aim of the study was to compare the efficacy of travoprost 0.004% eye drops added to therapy with timolol 0.5%. The study included 40 patients (80 eyes) with open angle glaucoma and intraocular pressure (IOP) above 18 mm Hg treated with topical beta blocker (timolol 0.50% twice a day). Travoprost 0.004% was added to timolol 0.5% therapy once daily in the evening. Follow up examinations were scheduled at 7 days, one month and three months. IOP lowering was achieved in all patients. Substantial lowering of 2.42 mm Hg was achieved after the first week of treatment. Further lowering and stabilization of IOP was recorded at three months, with total IOP decrease of 3.97 mm Hg; the difference was statistically significant (χ2=6.7743; p<0.01). At three months, target IOP was recorded in 64 eyes (16.4±0.7 mm Hg) and failed to be achieved in 16 eyes (21.1±2.3 mm Hg). Mild hyperemia was found in two patients and discrete hyperemia in 26 patients. Burning sensation associated with the use of travoprost 0.004% eye drops was reported by 68 patients. In conclusion, the use of travoprost 0.004% eye drops resulted in successful lowering of IOP and achievement of target IOP.Cilj studije bio je ispitati uspješnost terapije travoprostom 0.004% pridodanog već postojećoj terapiji timololom 0,5%. U studiju je bilo uključeno 40 bolesnika s glaukomom otvorenog kuta i intraokularnim tlakom (IOT) iznad 18 mm Hg liječenih lokalnim beta blokatorom (timolol 0,5% dva puta na dan). Travoprost 0,004% se davao uz već postojeću terapiju jedanput na dan, navečer. Kontrolni pregledi uslijedili su nakon 7 dana, 1 mjeseca i 3 mjeseca. Sniženje IOT je postignuto kod svih bolesnika. Značajno sniženje IOT od 2,42 mm Hg postignuto je nakon tjedan dana terapije. Daljnje sniženje IOT se postiglo i stabiliziralo nakon 3 mjeseca, s ukupnim sniženjem od 3,97 mm Hg; razlika je bila statistički značajna (χ2=6,7743; p<0.01). Nakon 3 mjeseca ciljni tlak postignut je kod 64 očiju (16,4±0,7 mm Hg), a nije postignut kod 16 očiju (16,4±0,7 mm Hg). Blaga hiperemija utvrđena je kod dvoje, a diskretna hiperemija kod 26 bolesnika. Peckanje pri ukapavanju lijeka opisalo je 68 bolesnika. Zaključuje se kako je primjena kapi travoprosta 0.004% dovela do sniženja IOT i postizanja ciljnog tlaka
