A Campbell

AC Furmaniak

AE Tjonna

Anna Jervaeus

BF Piper

BW Penninx

Carl Johan Sundberg

CF Snyder

DE Lyon

DR Taaffe

E McAuley

GA Borg

H Waart van

Helene Rundqvist

HS Wu

J Cohen

J Drigny

J Schmitt

JE Bower

JF Meneses-Echavez

JK Vulpen van

JL Mayhew

JS Thum

Kate A. Bolam

KH Schmitz

KM Mustian

KS Courneya

KV Jaureguizar

L Adamsen

L Uwer

LB Dolan

LH Rubin

M Barbaric

M Browall

M Börjesson

M Carayol

Malin Backman

Maria Browall

ME Medysky

N Aguilar-Farias

N Green

N Helmond van

N Mutrie

N Ouerghi

N Travier

NJ Davies

NK Aaronson

O Minton

R Peto

R Stasi

RK Portenoy

S Casla

S Jakobsson

S Saibil

Sara Margolin

Sara Mijwel

SB Morris

SVW Schulz

T Saanijoki

T Schmidt

U Wisloff

Y Wengström

Yvonne Wengström

English

Abstract
                Purpose
                Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT–HIIT), and moderate-intensity aerobic and high-intensity interval training (AT–HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.
              
                Methods
                Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT–HIIT, AT–HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.
              
                Results
                The RT–HIIT group was superior to UC for CRF: total CRF (p = 0.02), behavior/daily life (p = 0.01), and sensory/physical (p = 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT–HIIT compared to declines shown in the UC group (p = 0.04). AT–HIIT significantly improved emotional functioning versus UC (p = 0.01) and was superior to UC for pain symptoms (p = 0.03). RT–HIIT reported a reduced symptom burden, while AT–HIIT remained stable compared to deteriorations shown by UC (p &lt; 0.01). Only RT–HIIT was superior to UC for total symptoms (p &lt; 0.01).
              
                Conclusions
                16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.
              
                Trial registration
                Clinicaltrials.gov Registration Number: NCT02522260.
              </jats:sec

Crossref

Breast Cancer Research and Treatment

Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial

https://link.springer.com/content/pdf/10.1007%2Fs10549-017-4571-3.pdf

Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial

Abstract

Similar works

Full text

Available Versions

Crossref