A Wietzorrek

A Ökesli

AC Minder

B Gust

C Hoischen

D Oursel

DA Widdick

David Widdick

E Alves

HG Sahl

HJ Hong

I Oliynyk

JN Steenbergen

K Hosoda

K Iwamoto

K Wakamatsu

KE Rudder de

L Foulston

LT Fernández-Martínez

M Zhao

MA Gregory

Mervyn Bibb

PG Arnison

S Kodani

Sean O’Rourke

English

Abstract
               Streptomyces cinnamoneus DSM 40646 produces the Class II lantibiotic cinnamycin which possesses an unusual mechanism of action, binding to the membrane lipid phosphatidylethanolamine (PE) to elicit its antimicrobial activity. A comprehensive analysis of the cinnamycin biosynthetic gene cluster has unveiled a novel mechanism of immunity in which the producing organism methylates its entire complement of PE prior to the onset of cinnamycin production. Deletion of the PE methyl transferase gene cinorf10, or the two-component regulatory system (cinKR) that controls its expression, leads not only to sensitivity to the closely related lantibiotic duramycin, but also abolishes cinnamycin production, presumably reflecting a fail-safe mechanism that serves to ensure that biosynthesis does not occur until immunity has been established.</jats:p

Crossref

Journal of Industrial Microbiology & Biotechnology

A novel mechanism of immunity controls the onset of cinnamycin biosynthesis in <i>Streptomyces cinnamoneus</i> DSM 40646

https://link.springer.com/content/pdf/10.1007%2Fs10295-016-1869-9.pdf

A novel mechanism of immunity controls the onset of cinnamycin biosynthesis in Streptomyces cinnamoneus DSM 40646

A novel mechanism of immunity controls the onset of cinnamycin biosynthesis in Streptomyces cinnamoneus DSM 40646

Abstract

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