Intravascular lymphoma (IVL) is a rare disease characterized by the proliferation of neoplastic cells in the small
blood vessels that frequently goes undiagnosed until the time of autopsy. The neoplastic cells are usually of B-cell origin.
The clinical course was examined to determine factors that would facilitate antemortem diagnosis. IVL is observed with
clinical, histopathological and immunohystochemical methods. This is a unique case because the thyroid gland is a rare
place for IVL. Accent is given on immunohystochemical methods and tissue biopsy in the differential diagnosis of IVL
when nervous system and thyroid gland dysfunction occur. This report indicates that micro-ecosystem of multinodular
goitrous might influence the expression of chemokines and/or adhesion moleculs on endothelial and lymphoma cells,
leading to heavy infiltration of thyroid gland. Concurrently, that may guide the physician to tissue biopsy facilitating antemortem
diagnosis and institution of appropriate therapy
