Faculty of Veterinary Medicine University of Zagreb
Abstract
One of the numerous complications which could occur in babesiosis of dogs is disturbance in the coagulation system. The protein C pathway is one of the three major anticoagulant mechanisms and its activity was investigated in dogs with babesiosis, before and after therapy. We determined the decrease of protein C activity, which could be the consequence of inflammatory cytokines releasing, reduced synthesis in the liver, or increased erythropoietin production. Decrease in number of red blood cells and haematocrit could be due to mechanical, immuno-mediated or toxic-mediated haemolysis. Activity of aspartate-aminotransferase and alanine-aminotransferase and total bilirubin concentration was increased, indicating cellular damage of the liver.Jedna od mnogobrojnih komplikacija koja se može javiti kod babezioze pasa je poremećaj u sustavu grušanja krvi. Protein C je jedan od tri glavna čimbenika antikoagulacije, a njegova aktivnost je istraživana u pasa s babeziozom, prije i nakon terapije. Zabilježen je pad aktivnosti proteina C, što može biti posljedica oslobađanja upalnih citokina, smanjene sinteze u jetri ili povećane proizvodnje eritropoietina. Sniženje broja eritrocita i hematokrita može biti rezultat mehaničke ili imunološki posredovane hemolize ili hemolize uzrokovane oslobađanjem toksina. Aktivnost aspartat-aminotransferaze i alanin-aminotransferaze i koncentracija ukupnog bilirubina bila je povećana, što upućuje na oštećenja jetrenih stanica