AF Steinert

AJ Hayes

AM Craft

B Mollon

BC Heng

BD Elder

BO Diekman

C Foss

C Vinatier

CH Lee

CH Li

CR Lee

D Gawlitta

D Kyurkchiev

DA Grande

DJ Huey

DL Cohen

E Tognana

F Munarin

FPW Melchels

G Knutsen

GA Di Lullo

H Madry

H Muir

H Nagaya

H Nejadnik

H Park

H Shin

J Elisseeff

JC Hu

JPA Arokoski

JY Ko

K Hambly

K Pelttari

KL Caldwell

KL Spiller

KS Allan

LA McMahon

LA Vonk

M Brittberg

M Cucchiarini

M Pacifici

M Zscharnack

MB Goldring

MJ Webber

N Bhardwaj

N Mabvuure

N Quarto

NE Fedorovich

Q Hou

R Langer

R Mardones

R Ogawa

R Portner

R Stoop

R Tuli

RL Mauck

RM Schulz

S Bhumiratana

S Wakitani

SE Bae

T Garg

T Saito

TJ Klein

U Hansen

W Schuurman

WS Toh

XF Cui

Y Rais

Y Shen

YY Wei

English

AbstractFor a long time, cartilage has been a major focus of the whole field of tissue engineering, both because of the constantly growing need for more effective options for joint repair and the expectation that this apparently simple tissue will be easy to engineer. After several decades, cartilage regeneration has proven to be anything but easy. With gratifying progress in our understanding of the factors governing cartilage development and function, and cell therapy being successfully used for several decades, there is still a lot to do. We lack reliable methods to generate durable articular cartilage that would resemble the original tissue lost to injury or disease. The question posed here is whether the answer would come from the methods using cells, biomaterials, or tissue engineering. We present a concise review of some of the most meritorious efforts in each area, and propose that the solution will most likely emerge from the ongoing attempts to recapitulate certain aspects of native cartilage development. While an ideal recipe for cartilage regeneration is yet to be formulated, we believe that it will contain cell, biomaterial, and tissue engineering approaches, blended into an effective method for seamless repair of articular cartilage.</jats:p

Jonathan C. Bernhard

Gordana Vunjak-Novakovic

Crossref

Stem Cell Research & Therapy

Should we use cells, biomaterials, or tissue engineering for cartilage regeneration?

https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-016-0314-3?site=stemcellres.biomedcentral.com

Should we use cells, biomaterials, or tissue engineering for cartilage regeneration?

Abstract

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