Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
Simptomi alergije koji zahvaćaju oko su česti kako u djece tako i u odraslih u cijelom svijetu. Alergijska reakcija u oku kod sensibiliziranih osoba izaziva svrbež, kemozu spojnice, suzenje, crvenilo oka i otok vjeđa. Ovaj rad donosi preliminarne rezultate studije cilj koje je bio odrediti učinkovitost olopatadina u terapiji alergijskog konjunktivitisa. Studija je obuhvatila 20 osoba (11 žena i 9 muškaraca). Bolesnici su liječeni kapima za oči koje su sadržavale 1 mg/mL olopatadina. Promjene u znacima i simptomima su se bilježile 5 minuta nakon prvog ukapavanja i 15 dana nakon početka terapije. Nelagoda, svrbež, crvenilo oka, suzenje i osjećaj stranog tijela su se ocjenjivali ocjenom od 0 do 3. Statistička analiza prikupljenih podataka je pokazala da su se simptomi i znaci uspješno povukli nakon liječenja olopatadinom, ali je bio znatno učinkovitiji u bolesnika s akutnim nego u onih s kroničnim alergijskim poremećajima. Nije zabilježen niti jedan neželjeni učinak lijeka. Kako se radi o preliminarnim rezultatima, bolji uvid u djelotvornost olopatadina ćemo dobiti nakon provođenja čitave studije na puno većem broju ispitanika.Allergy symptoms that affect the eyes are common in adults and children worldwide. Ocular allergies cause itching, chemosis, tearing, redness, and swelling of the eyelids in sensitized individuals. This is a preliminary report on a study aimed at assessing the olopatadine therapy efficacy in resolving the signs and symptoms of allergic conjunctivitis. Twenty patients (11 female and 9 male) were included in the study. They were treated with olopatadine 1 mg/mL solution. Clinical effects were recorded at 5 minutes of the first application and at 15 days of continuous application. Discomfort, itching, eye redness, tearing and foreign body sensation were graded on a scale from 0 to 3. Statistical analysis showed that all symptoms and signs responded favorably to olopatadine therapy. The results also showed olopatadine to be more efficacious in patients with acute than in those with chronic allergic diseases. No side effects were recorded. As these are only preliminary results, more information will be available upon completion of the large-scale study
