Urinary Tract Infections - Current Issues in Pathogenesis and Treatment

Abstract

Infekcije mokraćnog sustava (IMS) jesu simptomatske, asimptomatske, akutne (prve ili pojedinačne), rekurentne, kronične, komplicirane i nekomplicirane. Klinički simptomi cistitisa i leukociturija dovoljan su razlog za počinjanje trodnevne empirijske antimikrobne terapije akutnoga nekompliciranog cistitisa u mladih žena. Urinokultura se mora učiniti prije počinjanja antimikrobne terapije u trudnica, dijabetičara, rekurentnih IMS, pijelonefritisa i ako nije bilo uspješnoga ranijeg liječenja. Liječiti treba sve simptomatske IMS, a asimptomatsku bakteriuriju samo u trudnica, dijabetičara, predškolske djece s abnormalnim urotraktom, novorođenčadi i prije urološko-ginekoloških zahvata te kod primalaca transplantiranog bubrega. Kod kompliciranih IMS važno je utvrditi i pokušati ukloniti ili bar staviti pod kontrolu čimbenike koji tu IMS čine kompliciranom. Za liječenje IMS upotrebljavaju se fluorokinoloni, betalaktamski antibiotici, aminoglikozidi, kotrimoksazol, nitrofurantoin i drugi. Cistitis se može liječiti 3 ili 7 dana, asimptomatska bakteriurija 3-7 dana, nekomplicirani pijelonefritis 10-14 dana. Za kronične i komplicirane IMS preporučuje se 7-14-dnevno liječenje samo u relapsima i reinfektima, a u odabranih bolesnika viπe tjedana do 6 mjeseci. Kemoprofilaksa rekurentnih nekompliciranih IMS provodi se najmanje 6 mjeseci.Urinary tract infections (UTI) are symptomatic, asymptomatic, acute (first or single), recurrent, chronic, complicated and uncomplicated. Clinical symptoms of cystitis and leukocituria are reasons enough to start a 3-day empiric antimicrobic therapy of acute uncomplicated cystitis in young women. Urinoculture must be done before the onset of antimicrobic therapy in pregnant women, diabetics, recurrent UTI, pyelonephritis, and in cases of unsuccessful previous treatment. Treated should be all symptomatic UTI, while asymptomatic bacteriuria should be treated only in pregnant women, diabetics, pre-school children with abnormal urinary tract, newborns and before urological-gynecological surgery as well as in receptors of transplanted kidney. In complicated UTI it is important to establish and to try to eliminate, or at least to control, factors which complicate the particular case. For treatment of UTI are used fluorokinolons, beta-lactamic antibiotics, aminoglykosides, cotrimoxazole, nitrofurantoin etc. Cystitis can be treated 3 or 7 days, asymptomatic bacteriuria 3 to 7 days, uncomplicated pyelonephritis 10 to 14 days. For chronic and complicated UTI 7 to 14 days treatment is recommended only in relapses and reinfections, and in chosen patients for several weeks, up to 6 months. Chemoprophylaxis of recurrent uncomplicated UTI is performed for at least 6 months

    Similar works