In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6-(2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.U nastavku istraživanja derivata piridina s potencijalnim protuupalnim djelovanjem sintetizirani su 4-alkoksi-2-(2-tienil ili furanil)-5H-[1]benzopirano[3,4-c]piridin-5-oni (2) i 2-alkoksi-4-amino-6-(2-tienil ili furanil)-3,5-piridindikarbonitrili (3). Smjesa spojeva 2 i 3 dobivena je reakcijom 1-(2-tienil ili furanil)-3-(2-hidroksifenil)-2-propen-1-ona (1) s malononitrilom u alkoholnoj otopini KOH. Neki od sintetiziranih spojeva testirani su na protuupalno i analgetsko djelovanje, uz diklofenak kalij kao pozitivnu kontrolu. U radu su dani detaljni sintetski, spektroskopski i toksikološki podaci
