Metabolički sindrom ili sindrom X nekoliko je
međusobno povezanih abnormalnosti koje povećavaju rizik
od nastanka kardiovaskularnih i cerebrovaskularnih bolesti.
To su dijabetes, hipertenzija, dislipidemija, hiperuricemija,
debljina, odnosno bolesti u kojih se na početku patofi ziološkog
slijeda nalazi inzulinska rezistencija.
S kliničkoga gledišta, hiperuricemija treba upozoriti kliničara
na povećani rizik od vaskularnih bolesti. Uloga urične
kiseline i njezina povezanost s inzulinskom rezistencijom,
kardiovaskularnim i cerebrovaskularnim bolestima, bubrežnim
bolestima i hipertenzijom, svaki dan postaje sve važnija
i jedan je od esencijalnih čimbenika u kliničkoj evaluaciji
i gradiranju fenomena metaboličkog sindroma i dijabetesa
tipa 2.Metabolic syndrome or syndrome X is a
complex association of several interrelated abnormalities
that increase the risk of cardiovascular and cerebrovascular
diseases. These diseases include diabetes, hypertension,
dyslipidaemia, hyperuricemia, obesity and other diseases
resulting from insulin resistance. From a clinical standpoint,
hyperuricemia should alert a clinician to an overall increased
risk of vascular diseases. The topical role of uric acid and its
relation to cardiovascular and cerebrovascular diseases and
insulin resistance, renal disease and hypertension is rapidly
evolving and it is one of essential factors in the clinical
clustering phenomenon of the metabolic syndrome and type
2 diabetes mellitus
