Antibiotici se upotrebljavaju 60-ak godina,
njima se mogu liječiti praktički sve danas poznate infekcije,
no, također, na njih se trajno razvija i rezistencija. U tekstu
se opisuje nastanak rezistencije, mehanizmi rezistencije, na
primjeru S. pyogenes i H. pylori odnos rezistencije i uporabe
antibiotika te potanko današnje stanje rezistencije glavnih
bakterijskih izvanbolničkih i bolničkih patogenih bakterija u
Hrvatskoj. Na temelju tih podataka upozorava se na potrebu
promjene empirijske antimikrobne terapije akutnih nekompliciranih
infekcija mokraćnog sustava, invazivnih salmoneloza i
πigeloza.Antibiotics have been in use for about 60
years, being applied in treatment of almost all today known
infections. However, resistance to them has been permanently
developing as well. In the text are described the emergence
of resistance, its mechanisms, the relationship of
resistance and use of antibiotics through the example of S.
pyogenes and H. pylori, and in detail is described the present
resistance of main pathogenic bacteria in Croatia (in community
and in hospitals). The obtained data point to the need of
changing the empirical antimicrobic therapy of acute non-complicated
infections of the urinary system, invasive salmonellosis
and shigellosis
