Sinteza i antimikotsko djelovanje 4-supstituiranih 3-(tiofen-2-il-metil)- Δ2-1,2,4-triazolin-5-tiona

Abstract

In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.Rekacijom hidrazida tiofen-2-octene kiseline (1) s izotiocijanatima sintetizirani su odgovarajući tiosemikarbazidi (2a-2g), a njihovom ciklizacijom u 2% NaOH 4-supstituirani 3-(tiofen-2-il-metil)-Δ2-1,2,4-triazolin-5-tioni (3a-3g). Ti spojevi su potencijalni antimikotici

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