Croatian Society of Gynaecology and Obstetrics, and Croatian Society of Perinatal Medicine of Croatian Medical Association
Abstract
Cilj rada. Istražiti nastaju li u posteljici trudnica starije životne dobi morfološke promjene koje mogu uzrokovati poremećaje tijeka trudnoće te fetalnog rasta i razvoja. Materijal i metode. Histomorfološki i kvantitativno smo stereološkim metodama analizirali 30 zrelih posteljica. Posteljice su podijeljene u dvije skupine, ovisno o životnoj dobi trudnice: a) posteljice trudnica od 35. do 45. godine (n=15) i b) posteljice trudnica od 20. do 35. godine (kontrolna skupina, n=15). Izmjereni su volumen posteljice (Vp) i porodna težina novorođenčeta (Tn). Izračunali smo volumensku gustoću (Vv) i totalni volumen (V) placentarnih resica, periviloznog fibrinoida i interviloznog prostora te usporedili ih u obje istraživane¬ skupine. Rezultati. U posteljica starijih trudnica značajno je manji volumenski udio placentarnih resica (p0,05). Zaključak. Rezultati pokazuju da u jednom cm3 posteljice trudnica starije životne dobi nastaju promjene prostornog rasporeda placentarnog parenhima, što se odnosi na statistički značajno manji udio placentarnih resica i značajno veći udio periviloznog fibrinoida. U mlađih i starijih trudnica slične vrijednosti totalnog volumena posteljice, njenih resica, periviloznog fibrinoida i interviloznog prostora te podjednake porodne težine novorođenčadi potvrđuju da se u posteljica starijih i mlađih trudnica jednako aktiviraju strukturni kompenzacijski mehanizmi. Oni osiguravaju dostatnu maternofetalnu izmjenu tvari; posteljice starijih trudnica funkcijski udovoljavaju potrebama normalnog rasta i razvoja fetusa kojem pripadaju.Objective. To investigate the presence of morphologic changes that may cause disorders in pregnancy course and fetal growth and development in older pregnant women’s placentas. The aim of the study was histomorphologi¬cally and quantitatively analyze term placentas of older pregnant women and investigate possible differences in their structure as compared to younger women’s placentas. Material and methods. A total of 30 term placentas were histomorphologically¬ and quantitatively analyzed by stereologic methods. The placentas were divided in two groups depending on the pregnant women’s age: a) placentas of pregnant women aged 35–45 years (N=15), and b) placentas of pregnant women aged 20–35 years (control group, N=15). Placenta volume (Vp) and newborns’ birthweight (Tn) were determined. Volume density (Vv) and total volume (V) of placental villi, perivillous fibrinoid and intervillous space were calculated and compared in both examined groups. Results. Placentas of the older pregnant women had significantly lower volume proportion of placental villi (p0.05). Conclusion. Results of quantitative analysis demonstrated that changes in the spatial arrangement of placental parenchyma¬ occurred¬ in one cm3 of older pregnant women and were related to a statistically significantly lower proportion of placental villi and significantly higher proportion of perivillous fibrinoid. Similar values established for younger and older pregnant women with regard to their total placenta volume, placental villi, perivillous fibrinoid, intervillous space and equal newborns’ birthweigh, supported the fact that structural compensatory mechanisms were equally activated in both younger and older women’s placentas. These mechanisms ensure sufficient maternofetal exchange; the older pregnant women’s placentas may equally meet the needs for normal growth and development of fetuses
