Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
Twenty patients (11 female and 9 male) with remitting relapsing multiple sclerosis were treated with beta interferon at University Department of Neurology, Sestre milosrdnice University Hospital. Thirteen patients were treated with interferon beta-1a (6 MIU 3 times weekly) and seven patients with interferon beta-1b (9.6 MIU every other day). The Expanded Disability Status Scale (EDSS) was recorded before interferon therapy and six months after initiation of interferon therapy. The mean EDSS score was slightly lower after six months of interferon therapy in both groups, but the difference was not statistically significant (p=0.17 in interferon beta-1a group and p=0.36 in interferon beta-1b group). Results in this small group of patients showed early improvement in the functional status of multiple sclerosis patients during interferon therapy. Further follow-up is required to get additional information on the course of functional improvement in multiple sclerosis patients after a
prolonged period of interferon therapy.Dvadesetoro (11 ženskih i 9 muških) bolesnika s remitentnom rekurentnom mulitiplom sklerozom liječeno je beta interferonom na Klinici za neurologiju Kliničke bolnice "Sestre milosrdnice" u Zagrebu. Trinaestoro bolesnika liječeno je interferonom beta-1a (6 MIJ 3 puta na tjedan), a sedmoro bolesnika interferonom beta-1b (9,6 MIJ svakog drugog dana). Ljestvica EDSS (Expanded Disability Status Scale) bilježena je prije i šest mjeseci od početka liječenja interferonom. Prosječan zbir na ljestvici EDSS bio je u objema skupinama nešto manji nakon šest mjeseci liječenja interferonom, ali razlika nije bila statistički značajna (p=0,17 u skupini na interferonu beta-1a i p=0,36 u skupini na interferonu beta-1b). Rezultati dobiveni u ovoj maloj skupini bolesnika pokazali su rano poboljšanje funkcijskog statusa u bolesnika s multiplom sklerozom za vrijeme liječenja interferonom. Potrebno je daljnje praćenje kako bi se dobili dodatni podaci o tijeku funkcijskog poboljšanja u bolesnika s multiplom sklerozom uz dugotrajno liječenje interferonom
