Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
The aim of the study was to compare central corneal thickness measurements among patients with pseudoexfoliation glaucoma, primary open angle glaucoma, and normal subjects. The study included 60 eyes divided into three groups: group 1 of 24 eyes pseudoexfoliation glaucoma; group 2 of 20 eyes with primary open angle glaucoma; and group 3 of 16 normal eyes. Central corneal thickness was measured using an ultrasound pachymeter, and intraocular pressure was measured by use of applanation tonometer. Statistical methods were employed on between-group comparison of the values obtained by central corneal thickness measurement. The mean central corneal thickness was similar across the three study groups, with no statistically significant difference among normal eyes, open angle glaucoma eyes and pseudoexfoliation glaucoma eyes (mean ± SD: 570±40, 558±41 and 564±25 mm, respectively). Accordingly, central cornea was not thinner in patients with pseudoexfoliation glaucoma than in either normal subjects or patients with open angle glaucoma. However, the possibility of differences that may have emerged in case of a larger sample size should also be taken in consideration. In conclusion, central corneal thickness was not demonstrated to be a risk factor for the development of pseudoexfoliation glaucoma in our patient series.Cilj ispitivanja bio je usporediti središnju debljinu rožnice u bolesnika sa pseudoeksfolijativnim glaukomom, primarnim glaukomom otvorenog kuta i zdravih ispitanika. Studija je obuhvatila podatke o 60 očiju podijeljenih u tri skupine. Prva je skupina uključivala 24 očiju osoba sa pseudoeksfolijativnim glaukomom, druga skupina 20 očiju bolesnika s primarnim glaukomom otvorenog kuta, a treća skupina 16 očiju zdravih osoba. Središnja debljina rožnice mjerila se ultrazvučnim pahimetrom, a očni tlak aplanacijskom tonometrijom. Nije bilo statistički značajne razlike srednje vrijednosti (±SD) središnje debljine rožnice između triju skupina, koja je mjerila 570±40 mm u kontrolnoj skupini zdravih očiju, 558±41 mm u skupini očiju s primarnim glaukomom otvorenog kuta i 564±25 mm u skupini očiju sa pseudoeksfolijativnim glaukomom. Dakle, nije utvrđena manja središnja debljina rožnice u bolesnika s pseudoeksfolijativnim glaukomom u usporedbi s onom kod bolesnika s primarnim glaukomom otvorenog kuta i zdravih ispitanika. Nije dokazano da bi manja središnja debljina rožnice bila čimbenik rizika za nastanak pseudoeksfolijativnog glaukoma, iako se ne može isključiti mogućnost drukčijih rezultata uz veći broj ispitivanih bolesnika
