School of Dental Medicine, University of Zagreb, Croatian Dental Society - Croatian Medical Association
Abstract
Svrha je istraživanja ispitati djelotvornost mikonazolskog gela primijenjenog pomoću individualne termoplastične udlage kao prekonoćnog držača lijeka u liječenju protetskog palatitisa, u usporedbi s klasičnom primjenom lijeka koju je propisao proizvođač. Sudjelovala su 44 nositelja mobilnih stomatoloških gornjih nadomjestaka s dijagnosticiranim protetskim palatitisom. Ispitna skupina (n = 22) liječena je 2-postotnim gelom mikonazolima, a nanosio se tijekom noći u individualnu udlagu. Kontrolna skupina (n = 22) liječena je unošenjem 2,5 ml istog lijeka u usta četiri puta na dan. Određivali su se intenzitet upale i infi ciranosti. Provedeni su sljedeći klinički testovi: intenzitet upale prema Newtonu, veličina eritematoznih lezija na sluznici nepca ispod ležišta nadomjestka, digitalna termometrija sluznice i bris za kulturu Candida albicans. Zabilježeni su i podaci o starosti, higijeni proteze i nosi li pacijent protezu tijekom noći. Rezultati su pokazali bržu i potpuniju sanaciju protetskog palatitisa u ispitnoj skupini bolesnika u odnosu prema kontrolnoj. U ispitnoj skupini zapažena je i veća redukcija kolonija kulture Candida albicans, što upućuje na njihovu djelotvorniju eliminaciju iz usta primjenom lijeka novom metodom. Ta metoda dodatno potiče bolesnika da slijedi upute o terapiji i higijeni nadomjestka. Individualna udlaga kao okluzijski zavoj pokazala se djelotvornijom i bolesniku ugodnijom od liječenja klasično ordiniranim antimikotikom, što bi klinički moglo biti vrlo važno u liječenju protetskog palatitisa.The aim of this study was to evaluate the effect of miconazole gel delivered on a custom thermoformed tray as an overnight drug holder appliance in denture stomatitis treatment, in comparison with classic application as recommended by manufacturer. The investigation included 44 upper denture wearers, diagnosed with denture stomatitis. The experimental group (n = 22) applied 2% miconazole gel in custom tray for overnight wear. The control group (n = 22) applied 2,5 ml of the same drug 4 times a day in their mouth. Intensity of infl ammation and infection was evaluated. The clinical tests that were used were: infl ammation intensity according to Newton, extent of palatal mucosal erythematous surface below denture, digital thermometry, and swabs for Candida albicans cultures. Oldness and hygiene status of dentures were recorded, as well as habit of overnight denture wearing. The investigation revealed that denture stomatitis healed faster and better in the experimental group compared to control group. Greater Candida albicans culture colony count reduction was observed in experimental group, which suggests more effi cient elimination of Candida albicans from the mouth with novel method. This method motivates patients to adhere to treatment and appliance hygiene instructions. Custom splint as occlusive drug delivery showed to be more effective and more convenient for the patients than the same antimicotic drug, classically delivered, which might be clinically relevant in treatment of denture stomatitis
