Institute for Medical Research and Occupational Health
Abstract
This paper discusses the toxicity and antidotal effects of 32 compounds. Screening studies have shown that these compounds combined with atropine are effective antidotes against the organophosphate nerve agents Tabun and/or Soman, having a therapeutic factor equal or greater than 2.0 when tested in mice or rats. We analysed the results of these studies, and recommend that these compounds should be studied in more detail simultaneously with conventional antidotes (PAM-2, HI-6, Toxogonin, TMB-4) in order to assess whether they could broaden the choice of compounds now available for the treatment of organophosphate poisoning.U ovom su radu opisani toksičnost i protuotrovno djelovanje 32-ju spojeva (antidota) koji su se prema literaturnim podacima pokazali djelotvornima (kada se primijene uz atropin) pri eksperimentalnom trovanju životinja organofosfornim spojevima tabunom i somanom. Terapijski faktor, tj. omjer LD50 organofosfornog spoja u prisutnosti i odsutnosti tih antidota bio je jednak ili veći od 2.0 kada su spojevi testirani na miševima ili štakorima. Predlaže se da se ovi spojevi detaljnije istraže usporedo s konvencionalnim antidotima (PAM-2, HI-6, toksogonin, TMB-4) da bi se vidjelo bi li oni mogli proširiti izbor spojeva koji su danas na raspolaganju u terapiji i prevenciji otrovanja organofosfatima
