Salivary and Serous Values of Interleukin 6 and Basic Growth Factor of Fibroblasts in Patients with Planocellular Carcinoma

Abstract

U literaturi postoje podatci o ulozi interleukina 6 (IL-6) i bazičnoga čimbenika rasta fibroblasta (bFGF) u bolesnika s oralnim karcinomima, ali nema podataka o salivarnom IL-6 i bFGF u tih bolesnika. Svrha ovoga ispitivanja bila je odrediti vrijednosti salivarnog i serumskog IL-6 i bFGF u 35 bolesnika s planocelularnim karcinomom usne šupljine, dobi od 40-73 godine, prosječne dobi 54 godine. Kontrolna se je skupina sastojala od 23 zdrava sudionika, u dobi od 25 godina. Dobiveni podatci analizirani su Mann-Whitney U testom i vrijednosti manje od 0,001 smatrale su se statistički znatnima. Serumske vrijednosti IL-6 i bFGF nisu se znatno razlikovale između ispitne i kontrolne skupine. Povišene vrijednosti salivarnog IL-6 i bFGF ustanovljene su u oboljelih od planocelularnoga karcinoma u usporedbi s kontrolnom skupinom (p<0,001). Možemo zaključiti da povišene vrijednosti salivarnog IL-6 i bFGF u oboljelih od planocelularnoga karcinoma potječu od lokalne proizvodnje.Data can be found in the literature on the roles of interleukin 6 (IL-6) and basic growth factor of fibroblasts (bFGF) in patients with oral carcinomas, although there are no data on salivary IL-6 and bFGF in such patients. The aim of this study was to determine the values of salivary and serum IL-6 and bFGF in 35 patients with planocellular carcinoma of the oral cavity, aged 40 - 73 years (mean age 54 years). A control group consisted of 23 healthy participants, aged 25 years. The data obtained were analysed by Mann-Whitney U test and values of less than 0.001 were considered statistically significant. Serum values IL-6 and bFGF did not significantly differ between the examined and the control group. Increased values of salivary IL-6 and bFGF were determined in the patients with planocellular carcinoma compared with the control group (p<0.001). We can conclude that the increased values of salivary IL-6 and bFGF in patients with planocellular carcinoma originated from local production