The Application of Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: Which Applications are Evidence Based?

Abstract

Cilj je regenerativnog liječenja parodonta ponovno uspostaviti izgubljenu građu parodonta (t.j. obnova korijenskoga cementa, parodontnoga ligamenta i alveolarne kosti). Rezultati temeljnih istraživanja upućuju na važnu ulogu proteinskog derivata matriksa cakline (enamel matrix protein derivative, EMD) u cijeljenju oštećenja parodonta. Histološki rezultati pokusa na životinjama i izvješća o slučajevima u ljudi, pokazuju da se primjenom EMD-a pospješuje obnova parodonta. Štoviπe, klinička istraživanja upućuju na zaključak da se primjenom EMD-a pozitivno utječe na cijeljenje parodontnih rana u čovjeka. Cilj je ovoga preglednog rada, na osnovi postojećih podataka iznijeti koje su kliničke indikacije za regenerativnu primjenu EMD-a.The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of the enamel matrix protein derivative (EMD) in periodontal wound healing. Histological results of experiments in animals and of human case reports have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. The goal of the current overview is to present, based on the existing evidence, the clinical indications for regenerative therapy with EMD