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Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium
Authors
Catherine G. Dulac
Ian Tietjen
Jason Rihel
Publication date
1 January 2005
Publisher
'UPV/EHU Press'
Doi
Cite
Abstract
In order to gain insights into the regulatory control of neuronal diversity in the mammalian olfactory system, we have identified the transcriptional profile of individual olfactory neurons. A single cell microarray strategy was performed to search for candidate genes involved in the molecular specification of dorso-ventral zones of olfactory receptor (OR) expression. Several transcripts were identified that display differential expression in distinct OR zones, including a novel family of genes, the Lozenge-like (Lzl) genes which share sequence consensus motifs with Lozenge, a transcription factor involved in the patterning of the Drosophila olfactory and visual systems. © UBC Press
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Last time updated on 05/06/2019