AA Rashad

AK Sachdeva

D Parashar

DA Case

E Guantai

FE Koehn

G Molinari

GA Belov

H Malet

IH Chowdhury

IP Singh

J Mann

JE Voss

JW Li

JWH Li

K Hirneisen

L Pohjala

L-F Nothias-Scaglia

M Bourjot

M Lucas-Hourani

Mahmoud E. S. Soliman

MP Williamson

N Corlay

P Kaur

P-M Allard

PTV Nguyen

RR Teixeira

S Bhakat

S Kothandan

S Lee

S Mondal

Soumendranath Bhakat

T Wells

X Lamballerie de

English


            Abstract
            Chikungunya virus (CHIKV) is one of the re-emerging “neglected” tropical diseases whose recent outbreak affected not only Africa and South-East Asia but also several parts of America and Europe. To date, despite its serious nature, no antivirals or vaccines were developed in order to counter this resurgent infectious disease. The recent advancement in crystallography and availability of crystal structures of certain domains of CHIKV initiates the development of anti-CHIKV agents using structure-based drug design or synthetic medicinal chemistry approach. Despite the fact that almost 50 % of the new chemical entities against several biological targets were either obtained from natural products or natural product analogues, a very humble effort was directed towards identification of novel CHIKV inhibitors from natural products. In this review, besides a brief overview on CHIKV as well as the nature as a source of medicines, we highlight the current progress and future steps towards the discovery of CHIKV inhibitors from natural products. This report could pave the road towards the design of novel semi-synthetic derivatives with enhanced anti-viral activities.
          
          
            Graphical Abstract
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Crossref

Journal of Natural Medicines

Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective

https://link.springer.com/content/pdf/10.1007%2Fs11418-015-0910-z.pdf

Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective

Abstract

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