A Rey

AE Wolters

AS Zigmond

Catherine L Hough

D Elliott

D Tulsky

D Wechsler

Dale M Needham

DM Needham

DR Roalf

DW Dowdy

E Sacanella

E Wesley Ely

EG Tangalos

EJ Burker

Elizabeth R Pfoh

FL Woon

FM Radtke

GJ Peek

J Torgersen

James C Jackson

JC Jackson

JE Richards

JS Lin

JS Saczynski

JW Kim

Kitty S Chan

LA Newkirk

M Unroe

MA Matthay

MD Lezak

ME Charlson

ME Wilcox

MF Folstein

Minxuan Huang

NE Brummel

O Spreen

OD Guillamondegui

OJ Bienvenu

Pedro A Mendez-Tellez

Peter E Morris

PP Pandharipande

PS Kamath

R Galioto

Ramona O Hopkins

RJ Kiernan

RK Heaton

RM Reitan

RM Ruff

RO Hopkins

SY Kim

TD Girard

Timothy D Girard

TJ Iwashyna

TP Ross

TW Rice

Victor D Dinglas

WA Kukull

WJ Ehlenbach

ZS Nasreddine

English

Abstract
                Introduction
                The Mini-Mental State Examination (MMSE) is a common cognitive screening test, but its utility in identifying impairments in survivors of acute respiratory failure is unclear. The purpose of this study was to evaluate MMSE performance versus a concurrently administered detailed neuropsychological test battery in survivors of acute respiratory failure.
              
                Methods
                This cross-sectional analysis used data from the ARDSNet Long Term Outcomes Study (ALTOS) and Awakening and Breathing Controlled Trial (ABC). Participants were 242 survivors of acute respiratory failure. The MMSE and detailed neuropsychological tests were administered at 6 and 12 months post-hospital discharge for the ALTOS study, and at hospital discharge, 3 and 12 months for the ABC study. Overall cognitive impairment identified by the MMSE (score &lt;24) was compared to impairments identified by the neuropsychological tests. We also matched orientation, registration, attention, memory and language domains on the MMSE to the corresponding neuropsychological test. Pairwise correlations, sensitivity, specificity, positive and negative predictive values, and agreement were assessed.
              
                Results
                Agreement between MMSE and neuropsychological tests for overall cognitive impairment was fair (42 to 80%). Specificity was excellent (≥93%), but sensitivity was poor (19 to 37%). Correlations between MMSE domains and corresponding neuropsychological tests were weak to moderate (6 months: r = 0.11 to 0.28; 12 months: r = 0.09 to 0.34). The highest correlation between the MMSE and neuropsychological domains was for attention at 6 months (r = 0.28) and language at 12 months (r = 0.34).
              
                Conclusions
                In acute respiratory failure survivors, the MMSE has poor sensitivity in detecting cognitive impairment compared with concurrently administered detailed neuropsychological tests. MMSE results in this population should be interpreted with caution.
              </jats:sec

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Crossref

Critical Care

Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the Mini-Mental State Examination

https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-015-0934-5?site=ccforum.biomedcentral.com

Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the Mini-Mental State Examination

Abstract

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