12 May 2012. A Program on cultivating true leadership skills helped participants became more effective team members. Solving jigsaw puzzles using leaders’ portraits, putting leader related situations into drawings, stepping oneself into a leader’s shoe and playing games involving teamworking and leadership values were among the activities enjoyed by the participants of the CLIC program (Contemporary Leadership in Community)

Chung, Pui Khi

Crobach, Monique J T

Cryo-EM

Förster, Beatrix

Kuijper, Ed J

Sub Cryo - EM

Frontiers in Microbiology

Ahmad, Ibrahim

UMP Institutional Repository

13INSPIRING LEADERSHIP FOR HUMAN ADVANCEMENT MILIEUAhmad Ibrahim12 May 2012. A Program on cultivating true leadership skills helped participants became more effective team members. Solving jigsaw puzzles using leaders’ portraits, putting leader-related situations into drawings, stepping oneself into a leader’s shoe and playing games involving teamworking and leadership values were among the activities enjoyed by the participants of the CLIC program (Contemporary Leadership in Community). The program was held at Universiti Malaysia Pahang by the Human Sciences Department of Centre for Modern Languages and Human Sciences (CMLHS). Students of Sekolah Menengah Kebangsaan Sultanah Hajjah Kalsom, Bandar Damansara, Kuantan were the lucky participants of the program, which was facilitated by undergraduate students of UHM3012 (Contemporary Leadership in Community) course.The objectives of the program were to present role models of different professions for students to model after, to develop students’ self-confidence and to impart knowledge on leadership skills in conducting a project. Thus, prominent figures like Tan Sri Abdul Aziz Abdul Rahman, Tan Sri Syed Mokhtar Al-Bukhary, Lieutanant Adnan, Tan Sri P. Ramlee and Datuk Dr. Mani Jegathesan were among the leaders discussed. The participants were really into the activities, and they looked forward to coming again to UMP for different programs such as leaders on campus tour and leaders in language labs.CLIC: A PROGRAM ON CULTIVATING TRUE LEADERSHIP

CLIC: a pogram on cultivating true leadership

Clostridium difficile causes antibiotic- and healthcare-associated diarrhea, which is characterized by a high mortality rate (5-15%) and high recurrence rate of 20% or more. Therapeutic alternatives to antibiotics are urgently needed to improve the overall cure rate. Among these, therapeutic antibodies have shown promising results in clinical studies. Herein, the authors review current monoclonal and polyclonal anti- C. difficile antibodies that have entered the clinical development stage, either for systemic administration or by the oral route. The antibodies can be applied as monotherapy or in combination with standard-of-care to treat an infection with C. difficile or to protect from a recurrence. Bezlotoxumab is the first antibody for secondary prevention of recurrence of C. difficile infection approved by the regulatory agencies in US and Europe. The human monoclonal antibody is administered systemically to patients receiving oral standard-of-care antibiotics. Other antibodies are currently in the clinical pipeline, and some are intended for oral use. They show a good safety profile, high efficacy and low production costs, and can be considered promising therapies of the future. The most promising orally administered drug candidate is a bovine antibody from hyperimmune colostral milk, which is in an advanced clinical development stage. Which antibody will enter the market is dependent on its bioavailability at the site of infection as well as its activity against C. difficile toxins, protection against colonization and possible action on spore formation. The antibody must demonstrate a clear benefit in comparison with other available treatment options to be considered for use by clinicians

Utrecht University Repository

Application of antibody-mediated therapy for treatment and prevention of Clostridium difficile Infection

Molecular basis of bacterial pathogenesis, virulence factors and antibiotic resistanc

Forster, B.

Chung, P.K.

Crobach, M.J.T.

Kuijper, E.J.

Leiden University Scholary Publications

Application of Antibody-Mediated Therapy for Treatment and Prevention of Clostridium difficile Infection

Beatrix Förster

Pui Khi Chung

Monique J. T. Crobach

Ed J. Kuijper

Frontiers - Publisher Connector

Clostridium difficile causes antibiotic- and healthcare-associated diarrhea, which is characterized by a high mortality rate (5–15%) and high recurrence rate of 20% or more. Therapeutic alternatives to antibiotics are urgently needed to improve the overall cure rate. Among these, therapeutic antibodies have shown promising results in clinical studies. Herein, the authors review current monoclonal and polyclonal anti- C. difficile antibodies that have entered the clinical development stage, either for systemic administration or by the oral route. The antibodies can be applied as monotherapy or in combination with standard-of-care to treat an infection with C. difficile or to protect from a recurrence. Bezlotoxumab is the first antibody for secondary prevention of recurrence of C. difficile infection approved by the regulatory agencies in US and Europe. The human monoclonal antibody is administered systemically to patients receiving oral standard-of–care antibiotics. Other antibodies are currently in the clinical pipeline, and some are intended for oral use. They show a good safety profile, high efficacy and low production costs, and can be considered promising therapies of the future. The most promising orally administered drug candidate is a bovine antibody from hyperimmune colostral milk, which is in an advanced clinical development stage. Which antibody will enter the market is dependent on its bioavailability at the site of infection as well as its activity against C. difficile toxins, protection against colonization and possible action on spore formation. The antibody must demonstrate a clear benefit in comparison with other available treatment options to be considered for use by clinicians

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CLIC: a pogram on cultivating true leadership

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