The aim of the work. The experimental justification of the nasal gel’s composition under the conventional name “Phytorin-plus”.
Materials and Methods. In order to determine the rational concentration of the extract of licorice root and essential oils of Eucalyptus and Siberian pine in the gel microbiological studies were conducted on the basis of the Department of Microbiology, Virology and Immunology of the National University of Pharmacy in the laboratory of microbiological and immunological studies by diffusion to agar using reference strains of microorganisms Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653.
Studies of antiviral activity were carried out on the basis of the State Institution “InstituteofMicrobiologyand Immunology named by I. I. Mechnykov of the Academy of Medical Sciences of Ukraine”.
Results and Discussion. Based on the studies, the rational concentrations of active ingredients in the nasal gel “Phytorin -plus” were justified: extract of licorice root – 3 %, essential oil of Eucalyptus – 2 %, essential oil of Siberian pine – 1 %. The data obtained were confirmed with further experimental study of antimicrobial and antiviral properties of the finished dosage form.
Conclusions. The choice of the active substances of nasal gel under the conventional name “Phytorin –plus” for the treatment of rhinitis has been experimentally proved. Based on the data of the conducted microbiological studies, the concentrations of the extract of licorice root and essential oils in the composition of the medicinal preparation were grounded.
The presence of antiviral action of licorice root extract in relation to adenovirus was established for the first time. It was shown that the developed nasal gel is promising for further use in the therapy of rhinitis
