This paper presents our experience in the treatment of a patient affected by metastatic esophagogastric junction cancer with a high tumor burden and an incipient visceral crisis. The patient was treated with a combination of induction taxane-based chemotherapy, local radiotherapy and microwave ablation of residual liver metastases. The patient experienced a complete and durable response with long-term survival of more than 3 years, without any relevant acute or late side effects