Exogenous serotonin potentiates vagal reaction of the colon

Abstract

This study is dedicated to serotoninergic structures of the colon. Experiments were performed in 35 Chinchilla rabbits under general anesthesia, mechanical ventilation, bilateral vagotomy. Mechanical and electrical activity of the ascending colon was recorded during electrical stimulation of the peripheral part of the right n. vagi in intact animals and after serotonin adipate injection. It was found that serotonin potentiates vagal effects of the colon, but without effect on duration of reaction. Concluded that the serotoninergic structures of the colon are able to control the parasympathetic portion of the autonomic nervous system