Knowing how to classify retinopathy of prematurity is essential as it provides information on the prognosis and guides decision making about screening and treatment

Andrea Molinari

Dan Weaver

Subhadra Jalali

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 COMMUNITY EYE HEALTH JOURNAL | VOLUME 30 | NUMBER 99 | 2017  55 CLASSIFICATIONClassifying retinopathy of prematurity Knowing how to classify retinopathy of prematurity is essential as it provides information on the prognosis and guides decision making about screening and treatment.It is important to classify retinopathy of prematurity (ROP) in each eye, at each screening session. Doing so makes it possible to screen babies consistently and to make decisions about whether further screening is required and when, or whether laser treatment or surgical management is needed. The International Committee for the Classification of ROP1 has classified it using the following criteria:1 The severity of the ROP 2 The zone in the retina where ROP is found3 The extent of the ROP 4 Whether the retinal blood vessels are dilated and/or tortuous (pre-plus or plus disease) 5 Whether aggressive posterior ROP is presentThe severity of the ROPROP can develop when the immature retinal blood vessels have not reached the edge of the retina, known as the ora serrata.• Stage 1 ROP: Demarcation line. A whitish line is visible between the normally vascularised retina and the peripheral retina in which there are no blood vessels (Figure 1)• Stage 2 ROP: Visible ridge. The demarcation line develops into a ridge, with height and width, between the vascular retina and peripheral retina (Figure 2).• Stage 3 ROP: Blood vessels in the ridge. Blood vessels grow and multiply (proliferate) and are visible in the ridge (Figure 3).• Stage 4 ROP; Sub-total retinal detachment. Vitreoretinal surgery may be indicated (Figure 4).• Stage 5 ROP: Total retinal detachment. No treatment is usually possible (Figure 5). Figure 1 Stage 1 ROP: Demarcation line (arrow)Figure 2 Stage 2 ROP: The demarcation line becomes a ridge with both height and widthFigure 3 Stage 3 ROP: Abnormal blood vessels grow and multiply within the ridge Figure 4 Stage 4 ROP: Sub-total retinal detachment Figure 5 Stage 5 ROP: Total retinal detachment. Parents may notice this as something white in the eyesBOOST-NZDAI. AUKLAND DISTRICT HEALTH BOARDLYON DW AND WARREN DF. REVIEW OF OPTOMETRY 2006(143):12ICEHSUBHADRA JALALI  Andrea MolinariPediatricOphthalmologist:HospitalMetropolitano,Av. Mariana de JesusOe-8, Quito, Ecuador.Dan Weaver PediatricOphthalmologist:Billings Clinic,Billings, Montana,USA.Subhadra JalaliDirector: NewbornEye Health Alliance,(NEHA) and Director,Quality: LV PrasadEye Institute,Hyderabad, India.Reference1   International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2005;123(7): 991-9.56   COMMUNITY EYE HEALTH JOURNAL | VOLUME 30 | NUMBER 99 | 2017FLECK BW AND MCINTOSH N. NEOREVIEWS JAN 2009;10(1):E20-E30Figure 6 The three zones of ROPThe zones in the retina where ROP is foundThe three zones of ROP are centred on the optic disc (Figure 6). • Zone I is the small circle of retina around the optic disc. The radius of the circle is twice the distance from the macula to the centre of the optic disc• Zone II is the ring-shaped section of the retina surrounding zone I, which extends to the ora serrata on the nasal side• Zone III is a crescent-shaped area of temporal retina. ROP in zone I is more likely to progress and become severe than ROP in zones II or III.The extent of the ROPThe extent of disease is recorded as clock hours, in twelve 30o or 1-hour sections (Figure 6). The clock hours recorded are the total clock hours involved, not just the contiguous sectors.The presence of plus diseaseIn plus disease, retinal arterioles and venules near the optic disc are dilated and tortuous. In pre-plus disease the changes are less pronounced, or may not affect all the blood vessels (Figure 7). Figure 7 Plus disease: dilated and torturous veinsFigure 8 Aggressive posterior ROP (in zone I) Figure 9 Scarring after ROPThe presence of aggressive posterior ROP (AP-ROP)Aggressive posterior ROP (AP-ROP) is nearly always in zone I. The proliferating blood vessels are flat and difficult to see, and plus disease is always present (Figure 8).NOTE: It is very important to recognise AP-ROP as it can progress extremely quickly to retinal detachment. Treatment should be given within 48 hours.How the classification can be usedClassification of ROP guides decision making about screening and treatment. For example:• If immature retinal vessels are present, screening should be repeated • If ROP is in zones II or III (further away from the optic disc) and is at stage 1 or 2, without any plus disease, the prognosis is good and the ROP is likely to resolve without treatment. Repeat screening is required in 1–2 weeks.• If ROP is in zone I, or if it is Stage 3 with plus disease, or aggressive posterior ROP is present, urgent treatment is needed as the disease is very likely to progress to retinal detachment. Scarring after ROPUntreated ROP can sometimes heal with scarring in the peripheral retina and vitreous. This distorts the retina, leading to macular dragging or retinal folds. These signs are not included in the International Classification of ROP, but can be associated with loss of vision (Figure 9).ICEHICEHICEHCLASSIFICATION Continued

Classifying retinopathy of prematurity

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Classifying retinopathy of prematurity

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