Radiotherapy for massive, symptomatic splenomegaly has been used in a palliative setting since the early
1990’s. Massive splenomegaly may be seen in CML, CLL, hairy cell leukemia and splenic marginal zone
lymphomas, prolymphocytic leukemia, myeloproliferative disorders such as polycythaemia rubra, polycythaemia vera or essential thrombocytosis or myelofibrosis.
Splenic radiation therapy has been shown to be effective in palliation of the signs and symptoms due to
massive splenomegaly.
We present here one such case of myelofibrosis where the patient was treated with radiotherapy to the
spleen for symptomatic relief. The patient achieved excellent response to the treatment.
Key Words: Hematological conditions, massive splenomegaly, palliative radiotherapy