Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown pathogenesis. The frequency of SLE
with cavitary lesion manifestation is very rare and is thought to be due to infection or pulmonary embolism. A 19- year-old female diagnosed with SLE complicated by lupus nephritis and cavitary pulmonary lesion is presented in
this case report. Other diseases that can lead to such lesions were ruled out in the patient. The patient improved
briefly after the initiation of immunosuppressive therapy, but was unresponsive to supportive treatment due to
pneumothorax. Pneumothorax is caused by cavitary lesions and possibly bronchopleural fistulas β these later caused
respiratory distress and death. The patient did not show any improvement in the lesions after the initiation of
immunosuppressive therapy. This case report suggests that the differential diagnosis of cavitary lung lesions should
include SL