An experiment was conducted to study the effects of partial substitution of some organic fertilizers on the growth, yield and some physiological traits (elemental content, as well as phenolics, flavonoids and chlorophyll content of lepidium sativum as RCBD with three replications. Treatments were including control, (common soil) and different levels of vermicompost (10 and 20 %), poultry and cow manure substitution in soil. The results revealed that the highest plant height, root length, leaf widths and stem and root dry weight were observed with 10 and 20% of vermicompost. Chlorophyll a content had highest amount at 20% vermicompoust and chlorophyll b content had the highest amount with 10% vermicompost and cow manure substitution and for total flavonoids, 10 % vermicompost hold the highest data. For the elements, Zn content was affected by the poultry (120-122.7 µg/plant) and cow manure (119.7-123.3 µg/plant) substitution. Mn2+(341.8-378.6 µg/plant) and Fe2+ (733.3-800 µg/plant)compositional amounts were statistically affected by vermiconpost. K+content (7.4 mg/plant) were positively responded to cow manure and vermicompost (8.6 mg/plant) both at 20% substitution. The lowest data for Ca2+content was belonged to control (4.6 mg/plan). 20% poultry and cow manures affected N content of the plant. It seems that organic fertilizers substitution affects the soil characteristics and improves nutrients absorption and hence influences the vegetative growth, elemental content of plants tissue as well as the organic compounds pool. Finally, it is worthy of note that with the suitable management of organic fertilizers utilization we would be able to promote the yield and quality attributes of the plant in favor of nutritional and therapeutic plant properties
