The effect of organic fertilizers, chemical nitrogen and phosphorus on oil content and some of agronomic traits of safflower (Carthamus tinctorius), was studied in 2014. A factorial arrangement of treatments in a randomized complete block design with three replications was used. Animal manure treatments (M1= Control, M2= 20 ton.ha-1, M3= 40 ton.ha-1), and Chemical fertilizer treatments (F1= Control, F2= 50 kg.ha-1 of nitrogen + 25 kg.ha-1 of P2O5, F3= 100 kg.ha-1 of nitrogen + 50 kg.ha-1 of P2O5, F4= 150 kg.ha-1 of nitrogen + 75 kg.ha-1 of P2O5) were assigned in plots. In this study characteristics such as: stem diameter, number of sub branch, number of kernels per m-2, biological yield, phosphorus agronomic efficiency, grain weight of capitol, phosphorus physiological efficiency, oil content, nitrogen content of grain, number of unfertile capitol, phosphorus appear recovery and capitol diameter were assessed. Results indicated that the interaction effects of chemical fertilizer and animal manure on the characteristics such as: number of sub branch, biological yield, and nitrogen content of grain, phosphorus agronomic efficiency, phosphorus physiological efficiency and phosphorus appear recovery was significant. The maximum and minimum of phosphorus physiological efficiency (65.88 and 6.21 kg.kg-1) were obtained in treatment of 50 kg.ha-1 of nitrogen + 25 kg.ha-1 of P2O5 + 40 ton.ha-1 of animal manure and 50 kg.ha-1 of nitrogen + 25 kg.ha-1 of P2O5 + 20 ton.ha-1 of animal manure, respectively