Microbial colonization and nosocomial infections in preterm infants in the neurosurgical hospital

Abstract

Work is devoted to studying of microbial colonization and infection associated with health care in preterm infants with severe intraventricular hemorrhage (IVH) to evaluate the formation of antibiotic-resistant strains and the choice of treatment. In preterm with IVH complicated by progressive hydrocephalus revealed different variations of the colonization of hospital microorganisms, which changed over hospital treatment. The main microorganisms, which colonized mucosa of oropharynx, respiratory tract and intestines, were Gram negative bacteria multiresistant to antibiotics. In patients receiving long-term antibiotic therapy (1,5 months or more), despite the use of antifungal drugs, appeared fungal flora; in 15% of cases — types of Candida non-albicans. The cause of nosocomial ventriculitis in infants with post-hemorrhagic hydrocephalus in 70% had Gram positive organisms, in 30% — combined bacterial and fungal infection. When choosing a treatment strategy for these children must take into account the results of microbiological studies and antibiogram