Introduction Traumatic injuries and decays are the biggest challenges to the integrity of a young permanent
tooth .The aim of this study was to compare the biostimulating and repairing action of mineral trioxide
aggregate (MTA) and of the mineral aggregate with ceramic nanoparticles (BioAgreggate) with calcium
hydroxide action, in terms of clinical-radiological parameters, after vital pulp therapy in young permanent teeth
affected by dental caries or traumatic injury. Material and methods The study was conducted on a sample of
36 teeth from 31 patients of both sexes, aged between 7 and 15 years (mean 9.3 ± 1.9 years), divided into three
groups, and took place for a period of up to 4 years. Results The results concerning the effectiveness of the
three materials used were evaluated in terms of clinical and radiological manifestations. These were
significantly correlated (Ȥ2 = 35.3, r = 0.705, p = 0.003, 95% CI), the study demonstrating an important
differences between the three groups of teeth. Final evaluation showed a significant association (Ȥ2 = 18.69, r =
0.725, p = 0.001, 95% CI) between the material used and the final results. Conclusions Following clinical
aseptic procedures, after removing bacterial contamination, applying a bio-stimulative dressing and an
hermetic crown sealing, there are high chances (about 95%) that the pulp of a young permanent tooth, even
seeming irreversibly inflamed, to return to the original status and continue to exercise its functions with longterm
preservation of vitality