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Towards a polymeric binding mimic for cytochrome CYP2D6
Authors
Aisha Ali
Polyxeni Antonaki
Sarah Cheek
Daniel L. Rathbone
Publication date
15 May 2005
Publisher
'Elsevier BV'
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Abstract
A series of fluorescent molecularly imprinted polymers has been prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. Such polymers would have the possibility to form the sensing element in a high-throughput assay for the prediction of CYP2D6 affinity. The imprinted polymers possessed binding-dependent fluorescence. They re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One polymer in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably successful in recognising CYP2D6 substrates from a drug panel. © 2005 Elsevier B.V. All rights reserved
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Last time updated on 06/03/2017